Inter- and intramolecular photochemical reactions of fleroxacin

Elisa Fasani; Sandra Monti; Ilse Manet; Fedele Tilocca; Luca Pretali; Mariella Mella; Angelo Albini

doi:10.1021/ol900189v

Inter- and intramolecular photochemical reactions of fleroxacin

Org Lett. 2009 May 7;11(9):1875-8. doi: 10.1021/ol900189v.

Authors

Elisa Fasani¹, Sandra Monti, Ilse Manet, Fedele Tilocca, Luca Pretali, Mariella Mella, Angelo Albini

Affiliation

¹ Department of Organic Chemistry, University of Pavia, v. Taramelli 10, 27100 Pavia, Italy. elisa.fasani@unipv.it

PMID: 19385669
DOI: 10.1021/ol900189v

Abstract

In the cation formed by photoinduced C-F bond cleavage in fleroxacin, intramolecular reaction with the N-ethyl chain is prevented by the electron-withdrawing effect of fluorine and intermolecular attack by nucleophiles is facilitated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Fleroxacin / chemistry*
Models, Molecular*
Molecular Structure
Photochemistry

Substances

Fleroxacin