Vasculitis syndromes: LAMP-2 illuminates pathogenesis of ANCA glomerulonephritis

Xavier Bosch; Eduard Mirapeix

doi:10.1038/nrneph.2009.51

Vasculitis syndromes: LAMP-2 illuminates pathogenesis of ANCA glomerulonephritis

Nat Rev Nephrol. 2009 May;5(5):247-9. doi: 10.1038/nrneph.2009.51.

Authors

Xavier Bosch¹, Eduard Mirapeix

Affiliation

¹ Department of Internal Medicine, Hospital Clinic, Institut d'Investigació Biomédica August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain. xavbosch@clinic.ub.es

PMID: 19384321
DOI: 10.1038/nrneph.2009.51

Abstract

The discovery that antibodies to a bacterial antigen can cross-react with a mammalian protein to cause pauci-immune necrotizing and crescentic glomerulonephritis opens up new possibilities for the diagnosis and treatment of this condition.

Publication types

Comment
News

MeSH terms

Animals
Antibodies, Antineutrophil Cytoplasmic / immunology*
Glomerulonephritis / immunology*
Humans
Lysosomal Membrane Proteins / immunology*
Lysosomal-Associated Membrane Protein 2
Vasculitis / immunology*

Substances

Antibodies, Antineutrophil Cytoplasmic
LAMP2 protein, human
Lysosomal-Associated Membrane Protein 2
Lysosomal Membrane Proteins