Cardiac renewing: interstitial Cajal-like cells nurse cardiomyocyte progenitors in epicardial stem cell niches

J Cell Mol Med. 2009 May;13(5):866-86. doi: 10.1111/j.1582-4934.2009.00758.x. Epub 2009 Apr 20.

Abstract

Recent studies suggested that various cell lineages exist within the subepicardium and we supposed that this area could host cardiac stem cell niches (CSCNs). Using transmission electron microscopy, we have found at least 10 types of cells coexisting in the subepicardium of normal adult mice: adipocytes, fibroblasts, Schwann cells and nerve fibres, isolated smooth muscle cells, mast cells, macrophages, lymphocytes, interstitial Cajal-like cells (ICLCs) and cardiomyocytes progenitors (CMPs). The latter cells, sited in the area of origin of coronary arteries and aorta, showed typical features of either very immature or developing cardiomyocytes. Some of these cells were connected to each other to form columns surrounded by a basal lamina and embedded in a cellular network made by ICLCs. Complex intercellular communication occurs between the ICLCs and CMPs through electron-dense nanostructures or through shed vesicles. We provide here for the first time the ultrastructural description of CSCN in the adult mice myocardium, mainly containing ICLCs and CMPs. The existence of resident CMPs in different developmental stages proves that cardiac renewing is a continuous process. We suggest that ICLCs might act as supporting nurse cells of the cardiac niches and may be responsible for activation, commitment and migration of the stem cells out of the niches. Briefly, not only resident cardiac stem cells but also ICLCs regulate myocyte turnover and contribute to both cardiac cellular homeostasis and endogenous repair/remodelling after injuries.

MeSH terms

  • Adipocytes / cytology
  • Adipocytes / physiology
  • Animals
  • Cell Communication / physiology
  • Cell Differentiation / physiology
  • Extracellular Fluid / cytology
  • Female
  • Fibroblasts / cytology
  • Fibroblasts / physiology
  • Male
  • Mice
  • Microscopy, Electron, Transmission
  • Myocardium / cytology*
  • Myocytes, Cardiac / cytology*
  • Myocytes, Cardiac / physiology
  • Pericardium / cytology*
  • Stem Cell Niche / cytology*
  • Stem Cells / cytology*
  • Stem Cells / physiology