Here we report on a percutaneous endoscopic interlaminar approach using a side-firing Ho:YAG laser for the treatment of lumbar discal cyst with a successful clinical outcome. A 27-year-old man presented with left gluteal and leg pain due to a discal cyst at the L5-S1 level. A percutaneous endoscopic interlaminar approach was used to remove the cyst, achieving complete decompression of the nerve root. The symptoms were relieved and the patient was discharged the next day. A percutaneous endoscopic interlaminar approach using a side-firing Ho:YAG laser appears to be a suitable alternative treatment for selected patients with lumbar discal cysts.