Nanomolar Hg(II) detection using Nile blue chemodosimeter in biological media

Org Lett. 2009 May 21;11(10):2101-4. doi: 10.1021/ol900542y.

Abstract

A Nile blue-based chemodosimeter (1) was newly synthesized, and its application for detection of the Hg(2+) ion in 100% aqueous solution was demonstrated. Upon its addition into aqueous Hg(2+) ion solution, it exhibited a considerable blue-shift in its absorption and emission spectra, driven by a desulfurization reaction. Detection at an emission of 652 nm was extremely sensitive (less than 1.0 ppb), even in biological media such as blood plasma and albumin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Albumins / chemistry
  • Colorimetry
  • Fluorescent Dyes / chemistry*
  • Fluorometry
  • Mercury / analysis*
  • Mercury / blood
  • Molecular Structure
  • Nanotechnology
  • Oxazines / chemical synthesis*
  • Oxazines / chemistry*
  • Phenylthiourea / chemical synthesis*
  • Phenylthiourea / chemistry
  • Solubility
  • Water / chemistry

Substances

  • Albumins
  • Fluorescent Dyes
  • Nile blue-based chemodosimeter
  • Oxazines
  • Water
  • Nile Blue
  • Phenylthiourea
  • Mercury