Abstract
A convenient synthetic protocol was elaborated for creation of combinatorial libraries of 1-(R(1)-phenyl)-5-methyl-N-R(2)-1H-1,2,3-triazole-4-carboxamides. As starting materials, commercially available or readily prepared azides, amines, and diketene were selected for the reaction which has proceeded in a one-pot system with high yields and in short time.
MeSH terms
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Amines / chemical synthesis
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Amines / chemistry*
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Azides / chemical synthesis
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Azides / chemistry*
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Combinatorial Chemistry Techniques / economics
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Combinatorial Chemistry Techniques / methods*
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Lactones / chemical synthesis
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Lactones / chemistry*
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Small Molecule Libraries / chemical synthesis*
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Small Molecule Libraries / chemistry
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Small Molecule Libraries / economics
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Triazoles / chemical synthesis*
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Triazoles / chemistry
Substances
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1-(R1-phenyl)-5-methyl-N-R2-1H-1,2,3-triazole-4-carboxamide
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Amines
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Azides
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Lactones
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Small Molecule Libraries
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Triazoles
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diketene