One-pot multicomponent synthesis of 1-aryl-5-methyl-N-R2-1H-1,2,3-triazole-4-carboxamides: an easy procedure for combinatorial chemistry

J Comb Chem. 2009 May-Jun;11(3):481-5. doi: 10.1021/cc900012w.

Abstract

A convenient synthetic protocol was elaborated for creation of combinatorial libraries of 1-(R(1)-phenyl)-5-methyl-N-R(2)-1H-1,2,3-triazole-4-carboxamides. As starting materials, commercially available or readily prepared azides, amines, and diketene were selected for the reaction which has proceeded in a one-pot system with high yields and in short time.

MeSH terms

  • Amines / chemical synthesis
  • Amines / chemistry*
  • Azides / chemical synthesis
  • Azides / chemistry*
  • Combinatorial Chemistry Techniques / economics
  • Combinatorial Chemistry Techniques / methods*
  • Lactones / chemical synthesis
  • Lactones / chemistry*
  • Small Molecule Libraries / chemical synthesis*
  • Small Molecule Libraries / chemistry
  • Small Molecule Libraries / economics
  • Triazoles / chemical synthesis*
  • Triazoles / chemistry

Substances

  • 1-(R1-phenyl)-5-methyl-N-R2-1H-1,2,3-triazole-4-carboxamide
  • Amines
  • Azides
  • Lactones
  • Small Molecule Libraries
  • Triazoles
  • diketene