Fallen immortals

Cell. 2009 Apr 17;137(2):203-5. doi: 10.1016/j.cell.2009.04.008.

Abstract

The memory of somatic cell gene expression is reset in the germline in a process that is accompanied by dramatic changes in chromatin modifications. In this issue, Katz et al. (2009) show that the histone demethylase Lsd1/Spr-5 may participate in this resetting process in the worm, thereby preventing a decline in germ cell epigenetic stability and viability over ensuing generations.

Publication types

  • Comment

MeSH terms

  • Animals
  • Caenorhabditis elegans / cytology
  • Caenorhabditis elegans / embryology*
  • Caenorhabditis elegans / metabolism
  • Caenorhabditis elegans Proteins / genetics
  • Caenorhabditis elegans Proteins / metabolism
  • Epigenesis, Genetic*
  • Germ Cells / cytology*
  • Germ Cells / metabolism
  • Histones / metabolism
  • Oxidoreductases, N-Demethylating

Substances

  • Caenorhabditis elegans Proteins
  • Histones
  • Oxidoreductases, N-Demethylating
  • SPR-5 protein, C elegans