Tris(pyrazolyl)methane 99mtc tricarbonyl complexes for myocardial imaging

Leonor Maria; Célia Fernandes; Raquel Garcia; Lurdes Gano; António Paulo; Isabel Cordeiro Santos; Isabel Santos

doi:10.1039/b817451b

Tris(pyrazolyl)methane 99mtc tricarbonyl complexes for myocardial imaging

Dalton Trans. 2009 Jan 28:(4):603-6. doi: 10.1039/b817451b.

Authors

Leonor Maria¹, Célia Fernandes, Raquel Garcia, Lurdes Gano, António Paulo, Isabel Cordeiro Santos, Isabel Santos

Affiliation

¹ Departamento de Química, Instituto Tecnológico e Nuclear, Estrada Nacional, 10, Sacavém, Portugal.

PMID: 19378552
DOI: 10.1039/b817451b

Abstract

Novel ether-containing tris(pyrazolyl)methane chelators stabilize thefac-[99mTc(CO)3]+ moiety providing complexes with significant, fast and stable heart uptake, together with a extremely fast liver clearance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromatography, High Pressure Liquid
Heart / diagnostic imaging*
Humans
Organotechnetium Compounds* / pharmacokinetics
Tissue Distribution
Tomography, Emission-Computed, Single-Photon

Substances

Organotechnetium Compounds