Abstract
Nm23-H1 encodes nucleoside diphosphate kinase A (NDPK-A) and is known to have a metastasis suppressive activity in many tumor cells. However, it has many other functions as well. Recent studies have shown that the interacting proteins with Nm23-H1 which mediate the cell proliferation, may act as modulators of the metastasis suppressor activity. The interacting proteins with Nm23-H1 can be classified into 3 groups. The first group of proteins can be classified as upstream kinases of Nm23-H1 such as CKI and Aurora-A/STK15. The second group of proteins acts as downstream effectors for the regulation of specific gene transcriptions, GTP-binding protein functions, and signal transduction in Erk signal cascade. The third group of proteins can be classified as bi-directionally influencing binding partners of Nm23-H1. As a result, the interactions with Nm23-H1 and binding partners have implications in the biochemical characterization involved in metastasis and tumorigenesis.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aurora Kinase A
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Aurora Kinases
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Carrier Proteins / genetics
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Carrier Proteins / metabolism*
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Cell Line, Tumor
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Cell Proliferation
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Gene Expression Regulation, Neoplastic
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Genes, Tumor Suppressor*
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Humans
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Monomeric GTP-Binding Proteins / genetics
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Monomeric GTP-Binding Proteins / metabolism*
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NM23 Nucleoside Diphosphate Kinases / genetics
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NM23 Nucleoside Diphosphate Kinases / metabolism*
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Neoplasm Metastasis / genetics*
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Neoplasm Proteins / genetics
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Neoplasm Proteins / metabolism*
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Neoplasms / genetics
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Phosphoric Monoester Hydrolases
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Protein Serine-Threonine Kinases / genetics
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Protein Serine-Threonine Kinases / metabolism
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RNA-Binding Proteins
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Signal Transduction / physiology
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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Carrier Proteins
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NM23 Nucleoside Diphosphate Kinases
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Neoplasm Proteins
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RNA-Binding Proteins
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STRAP protein, human
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Transcription Factors
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AURKA protein, human
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Aurora Kinase A
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Aurora Kinases
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Protein Serine-Threonine Kinases
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PRUNE1 protein, human
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Phosphoric Monoester Hydrolases
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Monomeric GTP-Binding Proteins