Bronchial complications following lung transplantation

Transplant Proc. 2009 Apr;41(3):921-6. doi: 10.1016/j.transproceed.2009.01.047.

Abstract

Introduction: Bronchial complications owing to the airway anastomosis in lung transplantation are important causes of morbidity and mortality. They occur in up to 27% of cases as defined by stenosis, necrosis, and dehiscence. Treatment depends on the type of complication.

Objective: To report our experience to treat this complication.

Methods: Between 2000 and 2007, we performed 71 lung transplants of which 36 were bilateral. The total number of anastomoses was 107:52 to the right and 55 to the left. The telescoping technique was initially used (14 initial unilateral transplants), and after October, 2003 it was changed to an end-to-end anastomosis (57 transplants and 93 anastomoses).

Results: Eight patients developed bronchial complications including two that were bilateral. There were 4 stenosis, 3 dehiscences, and 3 necrosis complications (9.4%). The complication rate for telescoping anastomosis was 21.4%, and for the end-to-end technique, 7.5%. The treatment of the stenosis used metallic or plastic self-expandable stents. Two bronchial dehiscences resulted in case of bronchopleural fistulae, empyema, and death; the other patient experienced spontaneous resolution. Concerning bronchial necrosis, 1 patient developed fistulization to the pulmonary artery and massive hemoptysis, and the other with bilateral necrosis, a spontaneous resolution.

Conclusion: Our bronchial anastomosis complication rate was comparable with that in other reports. The rate for the telescoping technique was greater compared with the end-to-end technique. The treatment of bronchial stenosis with a self-expandable prosthesis showed good results.

MeSH terms

  • Adult
  • Anastomosis, Surgical / adverse effects
  • Anastomosis, Surgical / methods
  • Bronchial Diseases / epidemiology*
  • Female
  • Functional Laterality
  • Humans
  • Hypertonic Solutions
  • Lung Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Organ Preservation
  • Organ Preservation Solutions
  • Polypropylenes
  • Pulmonary Disease, Chronic Obstructive / surgery
  • Pulmonary Fibrosis / surgery
  • Retrospective Studies
  • Sutures
  • Treatment Outcome

Substances

  • Euro-Collins' solution
  • Hypertonic Solutions
  • Organ Preservation Solutions
  • Polypropylenes