In vivo 19F MR imaging and spectroscopy for the BNCT optimization

P Porcari; S Capuani; E D'Amore; M Lecce; A La Bella; F Fasano; L M Migneco; R Campanella; B Maraviglia; F S Pastore

doi:10.1016/j.apradiso.2009.03.065

In vivo 19F MR imaging and spectroscopy for the BNCT optimization

Appl Radiat Isot. 2009 Jul;67(7-8 Suppl):S365-8. doi: 10.1016/j.apradiso.2009.03.065. Epub 2009 Mar 27.

Authors

P Porcari¹, S Capuani, E D'Amore, M Lecce, A La Bella, F Fasano, L M Migneco, R Campanella, B Maraviglia, F S Pastore

Affiliation

¹ CNR-INFM SOFT, Department of Physics, Sapienza University of Rome, Piazzale Aldo Moro 2, Rome, Italy. paola.porcari@roma1.infn.it

PMID: 19375924
DOI: 10.1016/j.apradiso.2009.03.065

Abstract

The aim of this study was to evaluate in vivo the boron biodistribution and pharmacokinetics of 4-borono-2-fluorophenylalanine ((19)F-BPA) using (19)F MR Imaging ((19)F MRI) and Spectroscopy ((19)F MRS). The correlation between the results obtained by both techniques, (19)F MRI on rat brain and (19)F MRS on blood samples, showed the maximum (19)F-BPA uptake in C6 glioma model at 2.5h after infusion determining the optimal irradiation time. Moreover, the effect of L-DOPA as potential enhancer of (19)F-BPA tumour intake was assessed using (19)F MRI.

MeSH terms

Animals
Boron Compounds / pharmacokinetics*
Boron Compounds / therapeutic use
Boron Neutron Capture Therapy / methods*
Brain Neoplasms / metabolism
Brain Neoplasms / radiotherapy
Cell Line, Tumor
Fluorine / analysis*
Fluorine / pharmacokinetics*
Glioma / metabolism
Glioma / radiotherapy
In Vitro Techniques
Magnetic Resonance Imaging / methods*
Magnetic Resonance Spectroscopy / methods*
Male
Phenylalanine / analogs & derivatives*
Phenylalanine / pharmacokinetics
Phenylalanine / therapeutic use
Radiation-Sensitizing Agents / pharmacokinetics
Radiation-Sensitizing Agents / therapeutic use
Rats
Rats, Wistar
Tissue Distribution

Substances

Boron Compounds
Radiation-Sensitizing Agents
4-borono-2-fluorophenylalanine
Fluorine
Phenylalanine