Radioactive synthesis and biodistribution study of beta-elemene-99mTc(CO)3 conjugates

J Biol Inorg Chem. 2009 Aug;14(6):899-904. doi: 10.1007/s00775-009-0502-z. Epub 2009 Apr 10.

Abstract

Beta-elemene, (5S,7R,10S)-(-)-(1-methyl-1-vinyl-2,4-diisopropenylcyclohexane), is an anticancer agent from traditional Chinese herbal medicine. Three novel (99m)Tc(CO)(3)-beta-elemene conjugates were synthesized successfully, and compared with beta-elemene exhibited improved water solubility. A biodistribution and micro single photon emission computed tomography image study showed there is a visible accumulation in Lewis lung cancer tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carcinoma, Lewis Lung / diagnostic imaging
  • Carcinoma, Lewis Lung / metabolism
  • Female
  • Mice
  • Mice, Inbred C57BL
  • Octanols / chemistry
  • Organotechnetium Compounds / chemical synthesis*
  • Organotechnetium Compounds / chemistry
  • Organotechnetium Compounds / pharmacokinetics*
  • Radioactivity
  • Sesquiterpenes / chemistry*
  • Tissue Distribution
  • Tomography, Emission-Computed, Single-Photon
  • Water / chemistry

Substances

  • Octanols
  • Organotechnetium Compounds
  • Sesquiterpenes
  • beta-elemene
  • Water