Abstract
Beta-elemene, (5S,7R,10S)-(-)-(1-methyl-1-vinyl-2,4-diisopropenylcyclohexane), is an anticancer agent from traditional Chinese herbal medicine. Three novel (99m)Tc(CO)(3)-beta-elemene conjugates were synthesized successfully, and compared with beta-elemene exhibited improved water solubility. A biodistribution and micro single photon emission computed tomography image study showed there is a visible accumulation in Lewis lung cancer tumors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carcinoma, Lewis Lung / diagnostic imaging
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Carcinoma, Lewis Lung / metabolism
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Female
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Mice
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Mice, Inbred C57BL
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Octanols / chemistry
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Organotechnetium Compounds / chemical synthesis*
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Organotechnetium Compounds / chemistry
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Organotechnetium Compounds / pharmacokinetics*
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Radioactivity
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Sesquiterpenes / chemistry*
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Tissue Distribution
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Tomography, Emission-Computed, Single-Photon
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Water / chemistry
Substances
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Octanols
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Organotechnetium Compounds
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Sesquiterpenes
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beta-elemene
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Water