Detection of plasmid-mediated KPC-producing Klebsiella pneumoniae in Ottawa, Canada: evidence of intrahospital transmission

David Goldfarb; Sarah-Beth Harvey; Kelsi Jessamine; Peter Jessamine; Baldwin Toye; Marc Desjardins

doi:10.1128/JCM.00098-09

Detection of plasmid-mediated KPC-producing Klebsiella pneumoniae in Ottawa, Canada: evidence of intrahospital transmission

J Clin Microbiol. 2009 Jun;47(6):1920-2. doi: 10.1128/JCM.00098-09. Epub 2009 Apr 8.

Authors

David Goldfarb¹, Sarah-Beth Harvey, Kelsi Jessamine, Peter Jessamine, Baldwin Toye, Marc Desjardins

Affiliation

¹ Division of Microbiology, Department of Pathology and Laboratory Medicine, the Ottawa Hospital, 501 Smyth Rd., Ottawa, ON, Canada K1H 8L6.

Abstract

Klebsiella pneumoniae isolates from three patients admitted to the Ottawa Hospital, a 1,040-bed teaching hospital, were found to contain the plasmid-borne K. pneumoniae carbapenemase (KPC)-producing bla gene (bla(KPC)). There was evidence of person-to-person transmission for two patients. Screening of 186 clinical isolates revealed no additional bla(KPC)-containing isolates.

Publication types

Case Reports

MeSH terms

Aged
Aged, 80 and over
Anti-Bacterial Agents / pharmacology
Bacterial Proteins / biosynthesis*
Bacterial Proteins / genetics
Canada
Cross Infection / microbiology
Cross Infection / transmission*
DNA, Bacterial / genetics
Female
Genes, Bacterial
Humans
Klebsiella Infections / microbiology
Klebsiella Infections / transmission*
Klebsiella pneumoniae / enzymology*
Klebsiella pneumoniae / isolation & purification*
Male
Microbial Sensitivity Tests
Plasmids
beta-Lactamases / biosynthesis*
beta-Lactamases / genetics

Substances

Anti-Bacterial Agents
Bacterial Proteins
DNA, Bacterial
beta-Lactamases
beta-lactamase KPC-3, Klebsiella pneumoniae