Intracellular delivery of nanogel-quantum dot hybrid nanoparticles into human periodontal ligament cells

Tomoe Fukui; Hiroaki Kobayashi; Urara Hasegawa; Toshiyuki Nagasawa; Kazunari Akiyoshi; Isao Ishikawa

doi:10.2174/187231207780363570

Intracellular delivery of nanogel-quantum dot hybrid nanoparticles into human periodontal ligament cells

Drug Metab Lett. 2007 Apr;1(2):131-5. doi: 10.2174/187231207780363570.

Authors

Tomoe Fukui¹, Hiroaki Kobayashi, Urara Hasegawa, Toshiyuki Nagasawa, Kazunari Akiyoshi, Isao Ishikawa

Affiliation

¹ Section of Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan. fukui.peri@tmd.ac.jp

PMID: 19356032
DOI: 10.2174/187231207780363570

Abstract

Nanogels of cholesterol-bearing pullulan modified with amino-groups (CHPNH(2)) were utilized as a career to introduce quantum dots (QDs) into periodontal ligament (PDL) cells. Nanogel-QD effectively labeled PDL cells over 3 weeks. These results indicate that CHPNH(2)nanogels have a potential as a research tool in the studies of intracellular delivery system.

MeSH terms

Cells, Cultured
Cholesterol / administration & dosage*
Drug Delivery Systems
Glucans / administration & dosage*
Humans
Hydrogels / chemistry*
Nanotechnology / methods
Periodontal Ligament / cytology
Periodontal Ligament / metabolism
Quantum Dots*
Time Factors

Substances

Glucans
Hydrogels
pullulan
Cholesterol