Tarennanosides A-H, eight new lignan glucosides from Tarenna attenuata and their protective effect on H2O2-induced impairment in PC12 cells

Chem Biodivers. 2009 Apr;6(4):540-50. doi: 10.1002/cbdv.200800022.

Abstract

Eight new lignan glucosides, tarennanosides A-H (1-8, resp.), were isolated from the whole plant of Tarenna attenuata, together with three known compounds, fernandoside, (-)-lyoniresinol, and (-)-isolariciresinol. The planar structures of new compounds were elucidated mainly by analysis of physical and spectroscopic data, and the absolute configurations were determined by acid hydrolysis as well as CD spectroscopy. Compounds 1 and 2 exhibited potent antioxidant activities against H2O2-induced impairment in PC12 cells. Preliminary mechanism study by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method showed that these two compounds could act as radical scavengers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / chemistry*
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology
  • Biphenyl Compounds / chemistry
  • Biphenyl Compounds / pharmacology
  • Cell Line, Tumor
  • Chromatography, Gel
  • Chromatography, High Pressure Liquid
  • Glucosides / chemistry*
  • Glucosides / isolation & purification
  • Glucosides / pharmacology
  • Hydrogen Peroxide / chemistry*
  • Monosaccharides / chemistry*
  • Monosaccharides / isolation & purification
  • Monosaccharides / pharmacology
  • Naphthalenes / chemistry*
  • Naphthalenes / isolation & purification
  • Naphthalenes / pharmacology
  • PC12 Cells
  • Picrates / chemistry
  • Picrates / pharmacology
  • Rats
  • Rubiaceae / chemistry*

Substances

  • Antioxidants
  • Biphenyl Compounds
  • Glucosides
  • Monosaccharides
  • Naphthalenes
  • Picrates
  • lyoniresinol 2a-O-(6-O-(4-hydroxy-3,5-dimethoxy)benzoyl)-beta-D-glucopyranoside
  • Hydrogen Peroxide
  • 1,1-diphenyl-2-picrylhydrazyl