Bioreducible polymers for efficient gene and siRNA delivery

Biomed Mater. 2009 Apr;4(2):025020. doi: 10.1088/1748-6041/4/2/025020. Epub 2009 Apr 6.

Abstract

Bioreducible disulfide linkage-employing drug conjugate has already been approved for drug delivery application, and also has shown immense potential in gene and siRNA transfection. This paper will focus on the recent developments in bioreducible polymeric systems for gene and siRNA delivery application, and will discuss the advantages and challenges associated with reducible polymeric carriers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry*
  • Cell Line, Tumor
  • Disulfides / chemistry
  • Gene Transfer Techniques*
  • Genetic Therapy / instrumentation
  • Genetic Therapy / methods
  • Genetic Vectors
  • Humans
  • Models, Biological
  • Oxidation-Reduction
  • Polymers / chemistry*
  • RNA, Small Interfering / metabolism*
  • Transfection

Substances

  • Biocompatible Materials
  • Disulfides
  • Polymers
  • RNA, Small Interfering