A significant percentage of older adults experience a gradual decline in health, which influences their overall function, sense of well-being, and ability to perceive and participate in enjoyable life experiences. Personal and family history of depression further increases the likelihood of despair and mental decline related to aging. Consideration of selective serotonin reuptake inhibitors (SSRIs) as one form of treatment for depression is a clinically sound option; however, awareness of a potential side effect rarely reported in the general population yet prevalent among the elderly is essential: SSRI-induced hyponatremia with associated mental status impairment. Through knowledge, early recognition, and prompt intervention strategies, the clinician will be prepared to manage hyponatremia and reverse its serious consequences.