Abstract
Alpha-fetoprotein-producing metastatic adenocarcinoma of the stomach or the esophago-gastric junction usually exhibits either no or only short-term remission while receiving palliative chemotherapy. We report on a 76-year-old male patient suffering from an unresectable alpha-fetoprotein-producing adenocarcinoma of the esophago-gastric junction with several liver metastases. He was treated with capecitabine and oxaliplatin-based combination therapy. A long-lasting major remission was observed resulting in a survival of 18.5 months.
MeSH terms
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Adenocarcinoma / drug therapy*
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Adenocarcinoma / immunology
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Adenocarcinoma / pathology
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Aged
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
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Capecitabine
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Deoxycytidine / administration & dosage
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Deoxycytidine / analogs & derivatives
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Esophageal Neoplasms / drug therapy*
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Esophageal Neoplasms / immunology
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Esophageal Neoplasms / pathology
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Esophagogastric Junction / pathology*
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Fatal Outcome
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Fluorouracil / administration & dosage
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Fluorouracil / analogs & derivatives
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Humans
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Immunohistochemistry
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Liver Neoplasms / drug therapy*
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Liver Neoplasms / immunology
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Liver Neoplasms / secondary
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Magnetic Resonance Imaging
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Male
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Oxaloacetates
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Time Factors
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Treatment Outcome
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alpha-Fetoproteins / metabolism*
Substances
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AFP protein, human
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Oxaloacetates
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alpha-Fetoproteins
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Deoxycytidine
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Capecitabine
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Fluorouracil