2-Arylbenzofuran Derivatives from Morus cathayana

J Nat Prod. 2009 May 22;72(5):966-8. doi: 10.1021/np800789y.

Abstract

Four new 2-arylbenzofuran derivatives, cathafurans A (1), B (2), C (3), and D (4), were isolated from the stem bark of Morus cathayana. Their structures were determined by spectroscopic methods. Compounds 2 and 3 exhibited moderate activities against five human cancer cell lines, with IC(50) values ranging from 6.17 to 9.60 microg/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Benzofurans / chemistry
  • Benzofurans / isolation & purification*
  • Benzofurans / pharmacology
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Humans
  • Inhibitory Concentration 50
  • Molecular Structure
  • Morus / chemistry*
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Bark / chemistry

Substances

  • Antineoplastic Agents, Phytogenic
  • Benzofurans
  • Drugs, Chinese Herbal