Synthesis of a novel, optically active uridine analog containing a 1,4-dioxane sugar moiety. Synthesis of the corresponding dinucleotide

Nucleosides Nucleotides Nucleic Acids. 2009 Mar;28(3):220-37. doi: 10.1080/15257770902865407.

Abstract

A new optically active uridine nucleoside analogue in which a substituted 1,4-dioxane ring functioned as the sugar analogue was prepared from L-tartaric acid. The nucleoside analogue was further converted into the corresponding protected dinucleotide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dioxanes / chemistry*
  • Molecular Conformation
  • Molecular Structure
  • Nucleic Acid Conformation
  • Nucleosides / chemical synthesis*
  • Nucleosides / chemistry
  • Stereoisomerism
  • Uridine / chemistry*

Substances

  • Dioxanes
  • Nucleosides
  • 1,4-dioxane
  • Uridine