Abstract
A binaphthyl-based primary amine (R)- was designed for the Diels-Alder reaction of alpha-substituted alpha,beta-unsaturated aldehydes; in the presence of the TfOH salt of (R)-, the Diels-Alder reaction of alpha-substituted alpha,beta-unsaturated aldehydes with cyclopentadiene proceeded to afford the corresponding cycloadducts having one all-carbon quaternary stereocenter in good yield with good to high stereoselectivity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrolein / chemical synthesis
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Acrolein / chemistry
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Aldehydes / chemical synthesis
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Aldehydes / chemistry*
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Amines / chemical synthesis
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Amines / chemistry*
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Catalysis
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Cyclopentanes / chemical synthesis
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Cyclopentanes / chemistry
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Mesylates / chemical synthesis
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Mesylates / chemistry*
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Stereoisomerism
Substances
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Aldehydes
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Amines
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Cyclopentanes
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Mesylates
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Acrolein
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trifluoromethanesulfonic acid