Combinatorial library synthesis and biological evaluation of pyrazolo[4,3-e][1,4]diazepine as a potential privileged structure

ChemMedChem. 2009 May;4(5):733-7. doi: 10.1002/cmdc.200800453.

Authors

Ju-Yeon Lee¹, Yong-Chul Kim

Affiliation

¹ Research Center for Biomolecular Nanotechnology, Department of Life Science, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Buk-gu, Gwangju 500-712, Republic of Korea.

PMID: 19326385
DOI: 10.1002/cmdc.200800453

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amyloid Precursor Protein Secretases / antagonists & inhibitors
Amyloid Precursor Protein Secretases / metabolism
Aspartic Acid Endopeptidases / antagonists & inhibitors
Aspartic Acid Endopeptidases / metabolism
Azepines / chemical synthesis*
Azepines / chemistry
Azepines / pharmacology*
Cell Line
Combinatorial Chemistry Techniques
Crystallography, X-Ray
Humans
Purinergic P2 Receptor Antagonists
Receptor, Melanocortin, Type 4 / antagonists & inhibitors
Receptor, Melanocortin, Type 4 / metabolism
Receptors, Purinergic P2 / metabolism
Receptors, Purinergic P2X7
Structure-Activity Relationship

Substances

Azepines
P2RX7 protein, human
Purinergic P2 Receptor Antagonists
Receptor, Melanocortin, Type 4
Receptors, Purinergic P2
Receptors, Purinergic P2X7
Amyloid Precursor Protein Secretases
Aspartic Acid Endopeptidases
BACE1 protein, human