Grandine A, a new proaporphine alkaloid from the bark of Phoebe grandis

Mat Ropi Mukhtar; Ahmad Nazif Aziz; Noel F Thomas; A Hamid A Hadi; Marc Litaudon; Khalijah Awang

doi:10.3390/molecules14031227

Grandine A, a new proaporphine alkaloid from the bark of Phoebe grandis

Molecules. 2009 Mar 23;14(3):1227-33. doi: 10.3390/molecules14031227.

Authors

Mat Ropi Mukhtar¹, Ahmad Nazif Aziz, Noel F Thomas, A Hamid A Hadi, Marc Litaudon, Khalijah Awang

Affiliation

¹ Centre for Natural Products and Drug Discovery, Block D, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. matropi@um.edu.my

Abstract

The stem bark of Phoebe grandis afforded one new oxoproaporphine; (-)-grandine A (1), along with six known isoquinoline alkaloids: (-)-8,9-dihydrolinearisine (2), boldine, norboldine, lauformine, scortechiniine A and scortechiniine B. In addition to that of the new compound, complete 1H- and 13C-NMR data of the tetrahydroproaporphine (-)-8,9-dihydrolinearisine (2) is also reported. The alkaloids' structures were elucidated primarily by means of high field 1D- and 2D-NMR and HRMS spectral data.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry*
Alkaloids / isolation & purification
Aporphines / chemistry*
Aporphines / isolation & purification
Isoquinolines / chemistry
Isoquinolines / isolation & purification
Lauraceae / chemistry*
Magnetic Resonance Spectroscopy
Molecular Structure
Plant Bark / chemistry

Substances

Alkaloids
Aporphines
Isoquinolines
grandine A
scortechiniine A
scortechiniine B
boldine