Isolation of 2-pyridone alkaloids from a New Zealand marine-derived penicillium species

E Dilip de Silva; Anna-Skrollan Geiermann; Maya I Mitova; Philipp Kuegler; John W Blunt; Anthony L J Cole; Murray H G Munro

doi:10.1021/np800627f

Isolation of 2-pyridone alkaloids from a New Zealand marine-derived penicillium species

J Nat Prod. 2009 Mar 27;72(3):477-9. doi: 10.1021/np800627f.

Authors

E Dilip de Silva¹, Anna-Skrollan Geiermann, Maya I Mitova, Philipp Kuegler, John W Blunt, Anthony L J Cole, Murray H G Munro

Affiliation

¹ Department of Chemistry, University of Colombo, P.O. Box 1490, Colombo 3, Sri Lanka.

PMID: 19323568
DOI: 10.1021/np800627f

Abstract

Fermentation of a Penicillium sp. isolated from a surface-sterilized thallus segment of the brown alga Xiphophora gladiata, collected from Macrocarpa Point, Otago, New Zealand, in half-strength potato dextrose broth led to the isolation and characterization of three alkaloids: the known N-hydroxy-2-pyridone, PF1140 (1), and two new 2-pyridones, 2 and 3.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification*
Animals
Benzopyrans / chemistry
Benzopyrans / isolation & purification
Leukemia P388
Marine Biology
Mice
Molecular Structure
New Zealand
Penicillium / chemistry*
Phaeophyceae / microbiology
Pyridones / chemistry
Pyridones / isolation & purification*
Structure-Activity Relationship

Substances

Alkaloids
Benzopyrans
PF 1140
Pyridones
2-hydroxypyridine