Xylomexicanins A and B, new Delta14,15-mexicanolides from seeds of the Chinese mangrove Xylocarpus granatum

Z Naturforsch C J Biosci. 2009 Jan-Feb;64(1-2):37-42. doi: 10.1515/znc-2009-1-207.

Abstract

Two new mexicanolide-type limonoids, named xylomexicanin A (1) and xylomexicanin B (2), were isolated from seeds of the Chinese mangrove Xylocarpus granatum. Their structures were elucidated on the basis of spectroscopic methods. Compound 1 exhibited antiproliferative activity against human breast carcinoma cells (KT), while 2 did not show inhibitory effects on eleven human tumour cell lines tested.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Asia, Southeastern
  • Breast Neoplasms / drug therapy*
  • Cell Line, Tumor / drug effects
  • Female
  • Humans
  • Limonins / chemistry*
  • Limonins / isolation & purification
  • Limonins / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Medicine, Traditional
  • Meliaceae / chemistry*
  • Neoplasms / drug therapy*
  • Seeds / chemistry*

Substances

  • Antineoplastic Agents
  • Limonins