Abstract
Bioactivity-guided fractionation of extracts from the fungus IBWF79B-90A resulted in the isolation of three known naphthoquinones, herbarin, dehydroherbarin, and O-methylherbarin and the azaanthraquinone scorpinone as well as three structurally related derivatives, O-phenethylherbarin and herbaridines A and B. All seven compounds exhibited cytotoxic activities against several cell lines.
MeSH terms
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Animals
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Anthraquinones / chemistry
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Anthraquinones / isolation & purification
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Anthraquinones / pharmacology
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Ascomycota / chemistry*
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Ascomycota / growth & development
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Aza Compounds / chemistry
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Aza Compounds / isolation & purification
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Aza Compounds / pharmacology
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Bacteria / drug effects
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Bacteria / growth & development
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Cell Line, Tumor
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Cell Survival / drug effects
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Chromatography, High Pressure Liquid
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Humans
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Jurkat Cells
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Leukemia L1210
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Magnetic Resonance Spectroscopy
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Mice
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Microbial Sensitivity Tests
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Naphthoquinones / chemistry
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Naphthoquinones / isolation & purification*
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Naphthoquinones / pharmacology
Substances
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Anthraquinones
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Anti-Bacterial Agents
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Aza Compounds
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Naphthoquinones
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scorpinone
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herbarin