New naphthoquinone derivatives from the ascomycete IBWF79B-90A

Z Naturforsch C J Biosci. 2009 Jan-Feb;64(1-2):25-31. doi: 10.1515/znc-2009-1-205.

Abstract

Bioactivity-guided fractionation of extracts from the fungus IBWF79B-90A resulted in the isolation of three known naphthoquinones, herbarin, dehydroherbarin, and O-methylherbarin and the azaanthraquinone scorpinone as well as three structurally related derivatives, O-phenethylherbarin and herbaridines A and B. All seven compounds exhibited cytotoxic activities against several cell lines.

MeSH terms

  • Animals
  • Anthraquinones / chemistry
  • Anthraquinones / isolation & purification
  • Anthraquinones / pharmacology
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Ascomycota / chemistry*
  • Ascomycota / growth & development
  • Aza Compounds / chemistry
  • Aza Compounds / isolation & purification
  • Aza Compounds / pharmacology
  • Bacteria / drug effects
  • Bacteria / growth & development
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Chromatography, High Pressure Liquid
  • Humans
  • Jurkat Cells
  • Leukemia L1210
  • Magnetic Resonance Spectroscopy
  • Mice
  • Microbial Sensitivity Tests
  • Naphthoquinones / chemistry
  • Naphthoquinones / isolation & purification*
  • Naphthoquinones / pharmacology

Substances

  • Anthraquinones
  • Anti-Bacterial Agents
  • Aza Compounds
  • Naphthoquinones
  • scorpinone
  • herbarin