Abstract
Protease responsive nanosensors were obtained by the attachment of unique green fluorescent bifunctional 3-arylcoumarin-derived fluorogenic substrates to poly(acrylamide-co-N-(3-aminopropyl)methacrylamide) nanoparticles, in which proteolysis results in substantial signal amplification.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylic Resins / chemistry
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Coumarins / chemistry*
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Cross-Linking Reagents / chemistry
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry*
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Kinetics
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Nanostructures / chemistry*
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Peptide Hydrolases / metabolism*
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Peptides / chemistry*
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Peptides / metabolism*
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Reproducibility of Results
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Substrate Specificity
Substances
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Acrylic Resins
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Coumarins
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Cross-Linking Reagents
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Fluorescent Dyes
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Peptides
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polyacrylamide
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Peptide Hydrolases