Acylated flavonol bisdesmosides, sinocrassosides A3-A7 and B3, with aminopeptidase N inhibitory activity from Sinocrassula indica

Chem Biodivers. 2009 Mar;6(3):411-20. doi: 10.1002/cbdv.200800135.

Abstract

Six new acylated flavonol bisdesmosides, sinocrassosides A(3), A(4), A(5), A(6), A(7), and B(3) (1-6, resp.), were isolated from the MeOH extract of the whole plant of Sinocrassula indica. The structures of 1-6 were elucidated on the basis of chemical and physicochemical evidence. Among them, 2 and 6 which have an acyl group in the 3'''-position were found to show strong inhibitory effects on aminopeptidase N activity, which were stronger than that of curcumin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acylation
  • CD13 Antigens / antagonists & inhibitors*
  • Crassulaceae / chemistry*
  • Flavonols / chemistry
  • Flavonols / isolation & purification*
  • Flavonols / pharmacology*
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology*
  • Nuclear Magnetic Resonance, Biomolecular
  • Protease Inhibitors / isolation & purification*
  • Protease Inhibitors / pharmacology*

Substances

  • Flavonols
  • Glycosides
  • Protease Inhibitors
  • CD13 Antigens