Abstract
Six new acylated flavonol bisdesmosides, sinocrassosides A(3), A(4), A(5), A(6), A(7), and B(3) (1-6, resp.), were isolated from the MeOH extract of the whole plant of Sinocrassula indica. The structures of 1-6 were elucidated on the basis of chemical and physicochemical evidence. Among them, 2 and 6 which have an acyl group in the 3'''-position were found to show strong inhibitory effects on aminopeptidase N activity, which were stronger than that of curcumin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acylation
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CD13 Antigens / antagonists & inhibitors*
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Crassulaceae / chemistry*
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Flavonols / chemistry
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Flavonols / isolation & purification*
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Flavonols / pharmacology*
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology*
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Nuclear Magnetic Resonance, Biomolecular
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Protease Inhibitors / isolation & purification*
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Protease Inhibitors / pharmacology*
Substances
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Flavonols
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Glycosides
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Protease Inhibitors
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CD13 Antigens