Background: There are two rare variants of cutaneous T-cell lymphoma (CTCL) that primarily involve the subcutis. These include subcutaneous panniculitis-like T-cell lymphoma (SPTL) and cutaneous gamma/delta T-cell lymphoma.
Objective: This case report describes the clinical presentation, diagnosis, and treatment of a young man with probable SPTL. A review of recent literature outlining the differences between SPTL and cutaneous gamma/delta T-cell lymphoma is discussed.
Conclusion: The differential diagnosis in patients presenting with subcutaneous nodules and constitutional symptoms should include CTCL.