Abstract
The ABCC subfamily of proteins is composed of nine members in Leishmania. We report that all of these proteins have an intracellular localization and that the overexpression of at least four members, ABCC3, ABCC4, ABCC5, and ABCC7, can confer resistance to antimonials, the first-line drug against Leishmania.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
ATP-Binding Cassette Transporters / analysis
-
ATP-Binding Cassette Transporters / physiology*
-
Amino Acid Sequence
-
Animals
-
Antimony / pharmacology*
-
Drug Resistance
-
Leishmania / chemistry
-
Leishmania / drug effects*
-
Molecular Sequence Data
-
Protozoan Proteins / analysis
-
Protozoan Proteins / physiology*
-
Thyrotropin / analysis
Substances
-
ATP-Binding Cassette Transporters
-
Protozoan Proteins
-
Thyrotropin
-
Antimony