Intracellular localization of the ABCC proteins of Leishmania and their role in resistance to antimonials

Antimicrob Agents Chemother. 2009 Jun;53(6):2646-9. doi: 10.1128/AAC.01474-08. Epub 2009 Mar 23.

Abstract

The ABCC subfamily of proteins is composed of nine members in Leishmania. We report that all of these proteins have an intracellular localization and that the overexpression of at least four members, ABCC3, ABCC4, ABCC5, and ABCC7, can confer resistance to antimonials, the first-line drug against Leishmania.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP-Binding Cassette Transporters / analysis
  • ATP-Binding Cassette Transporters / physiology*
  • Amino Acid Sequence
  • Animals
  • Antimony / pharmacology*
  • Drug Resistance
  • Leishmania / chemistry
  • Leishmania / drug effects*
  • Molecular Sequence Data
  • Protozoan Proteins / analysis
  • Protozoan Proteins / physiology*
  • Thyrotropin / analysis

Substances

  • ATP-Binding Cassette Transporters
  • Protozoan Proteins
  • Thyrotropin
  • Antimony