Efficient one-pot synthesis of indol-3-yl-glycines via uncatalyzed Friedel-Crafts reaction in water

Mehdi Ghandi; Abuzar Taheri

doi:10.3390/molecules14031056

Efficient one-pot synthesis of indol-3-yl-glycines via uncatalyzed Friedel-Crafts reaction in water

Molecules. 2009 Mar 5;14(3):1056-61. doi: 10.3390/molecules14031056.

Authors

Mehdi Ghandi¹, Abuzar Taheri

Affiliation

¹ School of Chemistry, University College of Science, University of Tehran, Tehran, Iran. ghandi@khayam.ut.ac.ir

Abstract

The three component reaction of primary aliphatic amines, glyoxalic acid and indole or N-methylindole in water at ambient temperature affords indol-3-yl or N-methylindol-3-yl-glycine in almost quantitative yields.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines / chemistry
Glycine / chemical synthesis*
Glyoxylates / chemistry
Indoles / chemistry*
Water

Substances

Amines
Glyoxylates
Indoles
Water
glyoxylic acid
Glycine