Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages produced by Penicillium cecidicola FKI-3765-1: II. Structure elucidation

Hiroyuki Yamazaki; Satoshi Omura; Hiroshi Tomoda

doi:10.1038/ja.2009.19

Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages produced by Penicillium cecidicola FKI-3765-1: II. Structure elucidation

J Antibiot (Tokyo). 2009 Apr;62(4):207-11. doi: 10.1038/ja.2009.19. Epub 2009 Mar 20.

Authors

Hiroyuki Yamazaki¹, Satoshi Omura, Hiroshi Tomoda

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Kitasato University, Shirokane, Tokyo, Japan.

PMID: 19300471
DOI: 10.1038/ja.2009.19

Abstract

The structures of pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages produced by Penicillium cecidicola FKI-3765-1, were elucidated by spectroscopic studies, including various NMR experiments. Pentacecilides have a common pentacyclic meroterpene core, which contains an aromatic ring and a delta-lactone ring.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Hypolipidemic Agents / pharmacology*
Lipid Metabolism / drug effects*
Magnetic Resonance Spectroscopy
Mice
Molecular Conformation
Molecular Weight
Sesquiterpenes / pharmacology*
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet

Substances

Hypolipidemic Agents
Sesquiterpenes
pentacecilide A
pentacecilide B
pentacecilide C