Haliclonin A, a new macrocyclic diamide from the sponge Haliclona sp

Org Lett. 2009 Apr 16;11(8):1713-6. doi: 10.1021/ol900282m.

Abstract

Haliclonin A (1), a macrocyclic diamide of a novel skeletal class, was isolated from the marine sponge Haliclona sp. collected from Korean waters. The structure of this compound was determined using a combination of spectroscopic and chemical analyses. The new compound exhibited moderate cytotoxicity and antibacterial activity against diverse microbial strains.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Diamines / chemistry
  • Diamines / isolation & purification*
  • Diamines / pharmacology
  • Drug Screening Assays, Antitumor
  • Haliclona / chemistry*
  • Humans
  • K562 Cells
  • Macrocyclic Compounds / chemistry
  • Macrocyclic Compounds / isolation & purification*
  • Macrocyclic Compounds / pharmacology
  • Marine Biology
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular

Substances

  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Diamines
  • Macrocyclic Compounds
  • haliclonin A