Abstract
Haliclonin A (1), a macrocyclic diamide of a novel skeletal class, was isolated from the marine sponge Haliclona sp. collected from Korean waters. The structure of this compound was determined using a combination of spectroscopic and chemical analyses. The new compound exhibited moderate cytotoxicity and antibacterial activity against diverse microbial strains.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Diamines / chemistry
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Diamines / isolation & purification*
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Diamines / pharmacology
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Drug Screening Assays, Antitumor
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Haliclona / chemistry*
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Humans
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K562 Cells
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Macrocyclic Compounds / chemistry
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Macrocyclic Compounds / isolation & purification*
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Macrocyclic Compounds / pharmacology
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Marine Biology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Diamines
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Macrocyclic Compounds
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haliclonin A