This study examined critical points linked to the increase of surgical site infections in patients undergoing joint replacement. With this type of infection, it is not always possible to detect specific causes, and it often is necessary to perform a systematic review of assistance processes. Using Hazard Analysis Critical Control Points methodology, 4 stages of patients' pathway were identified: preoperative assessment, surgical procedure, postoperative assistance, and discharge. Surgical site infection risk factors were identified for each stage and categorized as patient conditions, staff and procedures, equipment, and environment.