Dye labelling of nucleosides

Chem Biol Drug Des. 2009 Apr;73(4):396-402. doi: 10.1111/j.1747-0285.2009.00792.x.

Abstract

Dye-labelled nucleosides were obtained in 30-79% (average 45%) yields by treating N-(4-arylazobenzoyl)-1H-benzotriazoles 3a-b with appropriate nucleosides. Similarly, 3a-b afforded dye-labelled threoninol conjugates in 55-89% (average 67%) yields. All novel products were characterized by NMR and elemental analysis.

MeSH terms

  • Amino Alcohols / chemical synthesis
  • Amino Alcohols / chemistry*
  • Azo Compounds / chemical synthesis
  • Azo Compounds / chemistry*
  • Butylene Glycols / chemical synthesis
  • Butylene Glycols / chemistry*
  • Coloring Agents / chemical synthesis
  • Coloring Agents / chemistry*
  • Magnetic Resonance Spectroscopy
  • Nucleosides / chemical synthesis
  • Nucleosides / chemistry*
  • Staining and Labeling / methods*
  • Triazoles / chemical synthesis
  • Triazoles / chemistry*

Substances

  • Amino Alcohols
  • Azo Compounds
  • Butylene Glycols
  • Coloring Agents
  • Nucleosides
  • Triazoles
  • threoninol
  • benzotriazole
  • azobenzene