This study aimed to establish a baseline data on regression of the levels of Lead (Pb), Nickel (Ni) and Vanadium (V) to specific size dimensions of selected marine organisms harvested from an oil spill zone of the Eastern Mediterranean Sea. Twenty samples of each of Siganus rivulatus, Mullets and oysters were collected from each of six harvest sites. A total of 1, 3, and 3 respective significant regression equations (p < 0.01) were established between Pb, Ni, V and specific size dimensions of the selected marine organisms. The significant correlation associated with the highest R (2) value was obtained between the Pb (y) level and the width (x) of the Siganus rivulatus (y = -86.833x + 417.72). The other six statistically significant correlations were associated with lower values of R (2) ranging between 0.338 and 0.380. This baseline data will be used in the future to evaluate the self-purification process of pollutants in different sizes of indicator-marine organisms in this part of the Mediterranean Sea.