Abstract
A series of benzene sulfonamides incorporating thio, sulfinyl or sulfonyl glycoside moieties were synthesized. These glycoconjugates were investigated for their ability to inhibit the enzymatic activity of four human carbonic anhydrases (hCA): isozymes I, II and tumour-associated isozymes IX and XII. The oxidation state of the sulfur in the carbohydrate tail moiety did not influence either enzyme inhibition potency or isozyme selectivity even though presenting opportunities for differing interactions with the target isozymes.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzene / chemistry*
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Benzene / metabolism
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Carbonic Anhydrase Inhibitors / chemical synthesis*
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Carbonic Anhydrase Inhibitors / metabolism
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Carbonic Anhydrases / metabolism*
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Galactosides / chemical synthesis
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Galactosides / metabolism
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Galactosides / pharmacology*
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Glycoconjugates / chemical synthesis*
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Glycoconjugates / pharmacology*
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Humans
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Isoenzymes / antagonists & inhibitors
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Isoenzymes / metabolism
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Sulfonamides / chemical synthesis
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Sulfonamides / metabolism
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Sulfonamides / pharmacology*
Substances
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4-(4-((2',3',4',6'-tetra-O-acetylgalactopyranosyl)oxymethyl)-1H-1,2,3-triazol-1-yl)benzenesulfonamide
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Carbonic Anhydrase Inhibitors
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Galactosides
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Glycoconjugates
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Isoenzymes
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Sulfonamides
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Carbonic Anhydrases
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Benzene