Delamination of the veneering composite is frequently encountered with fibre-reinforced composite (FRC) fixed dental prosthesis (FDPs). The aim of this study is to evaluate the influence of framework design on the load-bearing capacity of laboratory-made three-unit inlay-retained FRC-FDPs. Inlay-retained FRC-FDPs replacing a lower first molar were constructed. Seven framework designs were evaluated: PFC, made of particulate filler composite (PFC) without fibre-reinforcement; FRC1, one bundle of unidirectional FRC; FRC2, two bundles of unidirectional FRC; FRC3, two bundles of unidirectional FRC covered by two pieces of short unidirectional FRC placed perpendicular to the main framework; SFRC1, two bundles of unidirectional FRC covered by new experimental short random-orientated FRC (S-FRC) and veneered with 1.5 mm of PFC; SFRC2, completely made of S-FRC; SFRC3, two bundles of unidirectional FRC covered by S-FRC. Load-bearing capacity was determined for two loading conditions (n = 6): central fossa loading and buccal cusp loading. FRC-FDPs with a modified framework design made of unidirectional FRC and S-FRC exhibited a significant higher load-bearing capacity (p<0.05) (927+/-74 N) than FRC-FDPs with a conventional framework design (609+/-119 N) and PFC-FDPs (702+/-86 N). Central fossa loading allowed significant higher load-bearing capacities than buccal cusp loading. This study revealed that all S-FRC frameworks exhibited comparable or higher load-bearing capacity in comparison to an already established improved framework design. So S-FRC seems to be a viable material for improving the framework of FRC-FDPs. Highest load-bearing capacity was observed with FRC frameworks made of a combination of unidirectional FRC and S-FRC.