[Macular and multifocal electroretinography in the diagnosis of Stargardt's dystrophy]

Vestn Oftalmol. 2009 Jan-Feb;125(1):41-6.
[Article in Russian]

Abstract

Retinal bioelectrical activity was studied in Stargardt's dystrophy from the data of multifocal and macular electroretinography (M-ERG) and retinal morphometry was carried out. The group of 11 patients (22 eyes) with the central form of Stargardt's dystrophy showed reductions in the retinal density of a bioelectric response of a P1 component, the amplitude of N1 and P1 components in the area of 0 to 16 degrees, as well as decreases in the amplitude of M-ERG a- and b-waves and in the retinal thickness in the macular region. The mixed Stargardt's dystrophy group was characterized by reductions in the retinal density of an electrical response of a P1 component, in the amplitude of N1 and P1 components in the entire posterior pole in the area of 0 to 32 degrees, as well as decreases in the a- and b-waves of M-ERG, photopic, scotopic, and mixed ERG; the lowered retinal thickness was found in the foveal and parafoveal regions. A statistically significant relationship was established between the morphometric indices of the volume of the central retina, the amplitude of M-ERG b-wave, and the moderate retinal density of P1 component bioelectrical activity in the central regions.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Diagnosis, Differential
  • Electroretinography / methods*
  • Female
  • Humans
  • Macula Lutea / pathology
  • Macula Lutea / physiopathology*
  • Macular Degeneration / diagnosis*
  • Macular Degeneration / physiopathology
  • Male
  • Reproducibility of Results
  • Young Adult