Binary and ternary inclusion complexes of finasteride in HPbetaCD and polymers: preparation and characterization

Bioorg Med Chem. 2009 Apr 1;17(7):2718-23. doi: 10.1016/j.bmc.2009.02.044. Epub 2009 Feb 26.

Abstract

The aim of this study was to determine whether inclusion complexes between 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) and finasteride (FIN) are formed, and to characterize these. Equimolar FIN/HPbetaCD solid systems in the presence or absence of 0.1% (w/v) of polyvinylpyrrolidone K30 (PVP K30) or 0.3% of chitosan were prepared by coevaporation and freeze-drying methods. The systems were characterized by phase solubility, NMR, DSC, and XRD analysis. The results suggest that true binary and ternary inclusion complexes were formed.

MeSH terms

  • 2-Hydroxypropyl-beta-cyclodextrin
  • Calorimetry, Differential Scanning
  • Chitosan / chemistry
  • Finasteride / chemical synthesis
  • Finasteride / chemistry*
  • Freeze Drying
  • Magnetic Resonance Spectroscopy
  • Polymers / chemistry*
  • Povidone / chemistry
  • Solubility
  • X-Ray Diffraction
  • beta-Cyclodextrins / chemical synthesis
  • beta-Cyclodextrins / chemistry*

Substances

  • Polymers
  • beta-Cyclodextrins
  • 2-Hydroxypropyl-beta-cyclodextrin
  • Finasteride
  • Chitosan
  • Povidone