Registered nurses and physical therapists working in home healthcare are ideally situated to identify individuals with undiagnosed peripheral arterial disease (PAD). This article focuses on identifying PAD in the lower extremities. The purpose of this continuing education article is to assist the reader in recognizing the role of the home healthcare clinician in identifying and managing PAD. At completion of this module, participants will be able to identify key factors related to PAD, including use of the ankle-brachial index (ABI), and to identify individuals with the disease.