Communication breakdown: protein dynamics and drug design

Jeffrey W Peng

doi:10.1016/j.str.2009.02.004

Communication breakdown: protein dynamics and drug design

Structure. 2009 Mar 11;17(3):319-20. doi: 10.1016/j.str.2009.02.004.

Author

Jeffrey W Peng

PMID: 19278644
DOI: 10.1016/j.str.2009.02.004

Abstract

Mauldin et al. (2009) use NMR to show that drug binding can break up collective protein motions necessary for function. We discuss their findings in the context of drug discovery in pharmaceutical research.

Publication types

Comment
News

MeSH terms

Binding Sites
Drug Design*
Folic Acid Antagonists / chemistry*
Nuclear Magnetic Resonance, Biomolecular
Structure-Activity Relationship
Tetrahydrofolate Dehydrogenase / chemistry*
Tetrahydrofolate Dehydrogenase / metabolism

Substances

Folic Acid Antagonists
Tetrahydrofolate Dehydrogenase