Effect of quercetin on the gene expression profile of the mouse intestine

Biosci Biotechnol Biochem. 2009 Mar 23;73(3):722-5. doi: 10.1271/bbb.80484. Epub 2009 Mar 7.

Abstract

BALB/c mice were administered with quercetin or its derivatives (quercetin-3-glucoside, quercetin-4'-glucoside and rutin, 5 or 50 mg/kg BW) for 2 weeks. The mucosa of the small intestine were recovered and subjected to a microarray analysis using Affymetrix Mouse Genome 430 2.0 Array. A cluster analysis shows that only the "low dose group" had a significantly different gene expression profile from the negative control group.

MeSH terms

  • Animals
  • Cluster Analysis
  • Gene Expression Profiling*
  • Gene Expression Regulation / drug effects*
  • Intestinal Mucosa / metabolism*
  • Intestines / drug effects*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Quercetin / pharmacology*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism

Substances

  • RNA, Messenger
  • Quercetin