Identification of nobiletin, a polymethoxyflavonoid, as an enhancer of adiponectin secretion

Kazuhiro Kunimasa; Sachi Kuranuki; Nobuyasu Matsuura; Nozomi Iwasaki; Megumi Ikeda; Akira Ito; Yutaka Sashida; Yoshihiro Mimaki; Masamichi Yano; Mayumi Sato; Yasuhiro Igarashi; Tsutomu Oikawa

doi:10.1016/j.bmcl.2009.02.002

Identification of nobiletin, a polymethoxyflavonoid, as an enhancer of adiponectin secretion

Bioorg Med Chem Lett. 2009 Apr 1;19(7):2062-4. doi: 10.1016/j.bmcl.2009.02.002. Epub 2009 Feb 7.

Authors

Kazuhiro Kunimasa¹, Sachi Kuranuki, Nobuyasu Matsuura, Nozomi Iwasaki, Megumi Ikeda, Akira Ito, Yutaka Sashida, Yoshihiro Mimaki, Masamichi Yano, Mayumi Sato, Yasuhiro Igarashi, Tsutomu Oikawa

Affiliation

¹ Laboratory of Cell and Molecular Biology of Aging, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526, Japan.

PMID: 19268587
DOI: 10.1016/j.bmcl.2009.02.002

Abstract

Adiponectin, an adipocyte-derived protein with insulin-sensitizing, anti-diabetic and anti-atherogenic activities, is known to be induced during adipocyte differentiation. Nobiletin, a citrus polymethoxy flavonoid, was found to induce the differentiation of ST-13 preadipocytes into mature adipocytes and enhance the production of adiponectin protein at a concentration of 10 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adipocytes / drug effects
Adipocytes / metabolism*
Adipocytes / pathology
Adiponectin / genetics
Adiponectin / metabolism*
Animals
Cell Differentiation
Cell Line
Complement Factor D / metabolism
Fatty Acid-Binding Proteins / metabolism
Flavones / chemistry
Flavones / pharmacology*
Flavonoids / chemistry
Flavonoids / pharmacology
Mice
PPAR gamma / agonists
Up-Regulation

Substances

Adiponectin
Fabp4 protein, mouse
Fatty Acid-Binding Proteins
Flavones
Flavonoids
PPAR gamma
nobiletin
Complement Factor D