A radical bailout strategy for cancer stem cells

Zuzana Tothova; D Gary Gilliland

doi:10.1016/j.stem.2009.02.008

A radical bailout strategy for cancer stem cells

Cell Stem Cell. 2009 Mar 6;4(3):196-7. doi: 10.1016/j.stem.2009.02.008.

Authors

Zuzana Tothova¹, D Gary Gilliland

Affiliation

¹ Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. zuzana_tothova@hms.harvard.edu

PMID: 19265655
DOI: 10.1016/j.stem.2009.02.008

Abstract

In a recent issue of Nature, Diehn et al. (2009) demonstrate that breast cancer stem cells (CSCs) maintain lower levels of reactive oxygen species (ROS) than their nontumorigenic counterparts. Their studies provide a link between the management of ROS by CSCs and enhanced tumor radioresistance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Breast Neoplasms / metabolism*
Cell Proliferation
Mice
Neoplasm Recurrence, Local / metabolism
Neoplastic Stem Cells / metabolism*
Radiation Tolerance / physiology*
Radiation, Ionizing
Reactive Oxygen Species / metabolism*

Substances

Reactive Oxygen Species

Grants and funding

Howard Hughes Medical Institute/United States