Key endothelial signals required for hematopoietic recovery

Rebecca L Porter; Laura M Calvi

doi:10.1016/j.stem.2009.02.005

Key endothelial signals required for hematopoietic recovery

Cell Stem Cell. 2009 Mar 6;4(3):187-8. doi: 10.1016/j.stem.2009.02.005.

Authors

Rebecca L Porter¹, Laura M Calvi

Affiliation

¹ Wilmot Cancer Center and Endocrine Division, University of Rochester School of Medicine, 601 Elmwood Avenue, Box 693, Rochester, NY 14642, USA.

PMID: 19265650
DOI: 10.1016/j.stem.2009.02.005

Abstract

In this issue of Cell Stem Cell, Hooper et al. (2009) use a combination of immunohistochemistry and flow cytometry to characterize the bone marrow vasculature both before and after injury. The authors demonstrate that recovery of normal hematopoiesis after myelosuppressive insult is dependent upon endothelial VEGFR2.

Publication types

Comment

MeSH terms

Animals
Bone Marrow / blood supply*
Endothelium, Vascular / physiology*
Hematopoiesis / physiology*
Hematopoietic Stem Cells / physiology*
Mice
Vascular Endothelial Growth Factor Receptor-2 / physiology*

Substances

Vascular Endothelial Growth Factor Receptor-2

Abstract

Publication types

MeSH terms

Substances

Grants and funding