Interfacing glycosylated carbon-nanotube-network devices with living cells to detect dynamic secretion of biomolecules

Angew Chem Int Ed Engl. 2009;48(15):2723-6. doi: 10.1002/anie.200805514.

Abstract

A sense of cell-being: Single-walled carbon nanotubes (SWNTs) are functionalized with bioactive monosaccharides to enable their use as biosensors. The glycosylated nanotube network is biocompatible and can interface with living cells (see scheme) to electronically detect biomolecular release with high temporal resolution and high sensitivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biosensing Techniques / instrumentation*
  • Biosensing Techniques / methods
  • Glycosylation
  • Microscopy, Atomic Force
  • Monosaccharides / chemical synthesis
  • Monosaccharides / chemistry
  • Nanotubes, Carbon / chemistry*
  • PC12 Cells
  • Rats

Substances

  • Monosaccharides
  • Nanotubes, Carbon