Intrauterine insemination with or without mild ovarian stimulation in couples with male subfertility due to oligo/astheno- and/or teratozoospermia or antisperm antibodies: a prospective cross-over trial

Felice Francavilla; Filomena Sciarretta; Sara Sorgentone; Stefano Necozione; Riccardo Santucci; Arcangelo Barbonetti; Sandro Francavilla

doi:10.1016/j.fertnstert.2009.01.112

Intrauterine insemination with or without mild ovarian stimulation in couples with male subfertility due to oligo/astheno- and/or teratozoospermia or antisperm antibodies: a prospective cross-over trial

Fertil Steril. 2009 Sep;92(3):1009-1011. doi: 10.1016/j.fertnstert.2009.01.112. Epub 2009 Mar 3.

Authors

Felice Francavilla¹, Filomena Sciarretta², Sara Sorgentone², Stefano Necozione³, Riccardo Santucci², Arcangelo Barbonetti², Sandro Francavilla²

Affiliations

¹ Andrologic Unit, Department of Internal Medicine, University of L'Aquila, L'Aquila, Italy. Electronic address: francavi@cc.univaq.it.
² Andrologic Unit, Department of Internal Medicine, University of L'Aquila, L'Aquila, Italy.
³ Epidemiology, Department of Internal Medicine, University of L'Aquila, L'Aquila, Italy.

PMID: 19261275
DOI: 10.1016/j.fertnstert.2009.01.112

Abstract

Seventy-three couples with male subfertility, which was due to oligo/astheno- and/or teratozoospermia (n = 63) or antisperm antibodies (n = 10), were randomly assigned to sequential timed natural intercourse, intrauterine insemination (IUI) and IUI + mild ovarian hyperstimulation. From the analysis of 384 observed cycles, IUI was shown to be effective in oligo/asthenozoospermia without severe teratozoospermia, when it was associated with moderate multifollicular induction, and in male immunologic subfertility, IUI was highly effective in nonstimulated cycles also.

Publication types

Randomized Controlled Trial

MeSH terms

Antibodies, Anti-Idiotypic / adverse effects*
Asthenozoospermia / complications*
Clomiphene / pharmacology
Coitus / physiology
Cross-Over Studies
Female
Fertility Agents, Female / pharmacology
Humans
Infertility, Male / etiology*
Infertility, Male / therapy*
Insemination, Artificial / methods*
Live Birth
Male
Menotropins / pharmacology
Oligospermia / complications*
Ovary / drug effects
Ovulation Induction / methods*
Pregnancy
Pregnancy Rate
Prospective Studies
Spermatozoa / immunology*
Treatment Outcome

Substances

Antibodies, Anti-Idiotypic
Fertility Agents, Female
Clomiphene
Menotropins