Geraniol restores antibiotic activities against multidrug-resistant isolates from gram-negative species

Antimicrob Agents Chemother. 2009 May;53(5):2209-11. doi: 10.1128/AAC.00919-08. Epub 2009 Mar 2.

Abstract

The essential oil of Helichrysum italicum significantly reduces the multidrug resistance of Enterobacter aerogenes, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii. Combinations of the two most active fractions of the essential oil with each other or with phenylalanine arginine beta-naphthylamide yield synergistic activity. Geraniol, a component of one fraction, significantly increased the efficacy of beta-lactams, quinolones, and chloramphenicol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyclic Monoterpenes
  • Anti-Bacterial Agents / pharmacology*
  • Chloramphenicol / pharmacology
  • Dipeptides / chemistry
  • Dipeptides / pharmacology
  • Drug Resistance, Multiple, Bacterial / drug effects*
  • Drug Synergism
  • Gram-Negative Bacteria / classification
  • Gram-Negative Bacteria / drug effects*
  • Gram-Negative Bacteria / genetics
  • Helichrysum / chemistry*
  • Humans
  • Microbial Sensitivity Tests
  • Quinolones / pharmacology
  • Terpenes / pharmacology*
  • beta-Lactams / pharmacology

Substances

  • Acyclic Monoterpenes
  • Anti-Bacterial Agents
  • Dipeptides
  • Quinolones
  • Terpenes
  • beta-Lactams
  • phenylalanine arginine beta-naphthylamide
  • Chloramphenicol
  • geraniol