Nonlinear low-force elasticity of single-stranded DNA molecules

Phys Rev Lett. 2009 Feb 13;102(6):068301. doi: 10.1103/PhysRevLett.102.068301. Epub 2009 Feb 11.

Abstract

We reconcile single-molecule force-extension data with scaling theories of polymer elasticity: measurements of denatured single-stranded DNA show a regime where the extension grows as a nonlinear power law with force, in accordance with "tensile blob" models. Analysis of the salt dependence of this regime indicates that the polymer's Kuhn length is proportional to the Debye length; this contradicts the Odijk-Skolnick-Fixman theory, but agrees with other predictions. Finally, we identify a Theta condition of the polymer, and find that the wormlike chain model best describes the polymer's elasticity at this point.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • DNA, Single-Stranded / chemistry*
  • Elasticity
  • Models, Chemical*
  • Nonlinear Dynamics

Substances

  • DNA, Single-Stranded